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Polysubunit opioid prodrugs resistant to overdose and abuse
Polysubunit opioid prodrugs resistant to overdose and abuse
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机译:多ub津的阿片类药物耐服用和滥用药物
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摘要
The invention provides compositions and methods for the treatment or prevention of pain. The invention provides constructs whereby hydrolysis of the construct by a specified gastrointestinal enzyme directly, or indirectly, releases an opioid when taken orally as prescribed. The gastrointestinal enzyme mediated release of opioid from constructs of the invention is designed to be attenuated in vivo via a saturation or inhibition mechanism when overdoses are ingested. The invention further provides constructs that are highly resistant to oral overdose, chemical tampering, and abuse via non-oral routes of administration.
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