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METHODS FOR QUANTIFICATION OF NUCLEOSOME MODIFICATIONS AND MUTATIONS AT GENOMIC LOCI AND CLINICAL APPLICATIONS THEREOF
METHODS FOR QUANTIFICATION OF NUCLEOSOME MODIFICATIONS AND MUTATIONS AT GENOMIC LOCI AND CLINICAL APPLICATIONS THEREOF
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机译:用于定量基因组锁骨基因座和临床应用的核体修饰和突变的方法
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摘要
The invention relates to clinical applications of quantitative chromatin mapping assays, such as chromatin immunoprecipitation assays and assays using tethered enzymes (e.g., chromatin immunocleavage (ChIC) and cleavage under targets & release using nuclease (CUT&RUN®)). The methods may be used to detect and quantitate the presence of epigenetic modifications and mutations on nucleosomes (histones and/or DNA) from biological samples, monitor changes in the status of modifications and mutations, monitor the effectiveness of epigenetic and mutation therapies, select suitable treatments for a disease, determine the prognosis of a subject, identify biomarkers of a disease, and screen for agents that modify epigenetic or mutation status. The invention further relates to kits for use in the methods of the invention.
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