CHEMOENZYMATIC PROCESS FOR COPRODUCTION OF A DISULFIDE AND A SULFOXIDE OR A SULFONE

摘要

The present invention relates to a chemoenzymatic process for coproducing a disulfide and a sulfoxide or a sulfone from a composition M comprising: 1) a sulfide, 2) optionally an oxidizing agent, 3) an organic compound bearing at least one thiol moiety, 4) an enzyme E catalysing the oxidation of said sulfide to sulfoxide or to sulfone, 5) an enzyme D catalysing the formation of a disulfide bridge between two equivalents of said organic compound bearing at least one thiol moiety to form a dimer, and 6) a cofactor common to the two enzymes E and D; and also to a composition enabling in particular the implementation of this process. The present invention relates also to the use of a mercaptan for reducing a disulfide bridge formed between two equivalents of said organic compound bearing at least one thiol moiety, and more particularly to the use thereof as a regeneration substrate in the process described above.