Chemo-enzymatic process for the co-production of a disulfide and a sulfoxide or a sulfone

摘要

Chemo-enzymatic process for the co-production of a disulfide and a sulfoxide or a sulfone The present invention relates to a chemo-enzymatic process for the co-production of disulfide and sulfoxide or sulfone from a composition M comprising: a sulphide, optionally an oxidant, an organic compound carrying at least one thiol group, an enzyme E catalyzing the oxidation of said sulfide to sulfoxide or sulfone, an enzyme D catalyzing the formation of a disulfide bridge between two equivalents of said organic compound carrying at least one thiol group to form a dimer, and a cofactor common to the two enzymes E and D; as well as a composition allowing in particular the implementation of this process. The present invention also relates to the use of a mercaptan for the reduction of a disulfide bridge formed between two equivalents of an organic compound carrying at least one thiol group, and more particularly its use as a substrate for regeneration of the. method described above.