SINGLE-STRANDED NUCLEIC ACID MOLECULE FOR INDUCING -1 FRAME SHIFT AND COMPOSITION

摘要

The purpose of the present invention is to provide a substance which is capable of expressing a protein, said protein having an amino acid sequence more closely similar to the amino acid sequence of a normal protein, while preventing the reduction in the length thereof even from a gene having an out-of-frame mutation and which is safe to the living body, and a composition comprising this substance. The aforesaid purpose can be achieved by: a single-stranded nucleic acid molecule which comprises, in the direction from the 5'-terminal side to the 3'-terminal side, a first sequence complementary to the target sequence of a gene of interest and a second sequence forming a stem-loop structure; a composition which comprises the single-stranded nucleic acid molecule as an active ingredient, etc.