Use of fumaric acid esters and pharmaceutically acceptable salts thereof in preparing pharmaceuticals for treating ferroptosis-related diseases

摘要

Related is use of fumaric acid esters or pharmaceutically acceptable salts thereof in preparing a pharmaceutical for treating ferroptosis-related diseases. The fumaric acid esters includes dimethyl fumarate and/or monomethyl fumarate. The present application reveals, for the first time, the effect of fumaric acid ester and its pharmaceutically acceptable salt on a protein level of a ferroptosis key regulatory gene GPX4, provides a theoretical basis for the research of treatment strategies for the ferroptosis-related diseases, and provides a new outlet for preparing pharmaceuticals used for the ferroptosis-related diseases.