The present invention relates to a nucleic acid molecule encoding an RNA-guided DNA endonuclease, which is (a) a nucleic acid molecule encoding the RNA-guided DNA endonuclease comprising or consisting of the amino acid sequence of SEQ ID NO: 1 or 3; (b) a nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 2 or 4; (c) a nucleic acid molecule encoding a RNA-guided DNA endonuclease the amino acid sequence of which is at least 70 % identical to the amino acid sequence of (a); preferably at least 80 % identical, more preferably at least 90 % identical, and most preferred at least 95% identical; (d) a nucleic acid molecule comprising or consisting of a nucleotide sequence which is at least 70 % identical to the nucleotide sequence of (b), preferably at least 80 % identical, more preferably at least 90 % identical, and most preferred at least 95% identical; (e) a nucleic acid molecule which is degenerate with respect to the nucleic acid molecule of (d); or (f) a nucleic acid molecule corresponding to the nucleic acid molecule of any one of (a) to (d) wherein T is replaced by U.
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机译：本发明涉及编码RNA引导的DNA内切核酸酶的核酸分子，其是（a）编码包含或由SEQ ID NO：1或3的氨基酸序列组成的RNA引导的DNA内切核酸酶的核酸分子; （b）包含或由SEQ ID NO：2或4的核苷酸序列组成的核酸分子; （c）编码RNA引导的DNA内切核酸酶的核酸分子，其氨基酸序列与（a）的氨基酸序列相同的至少70％;优选地，至少80％相同，更优选至少90％相同，最优选的至少95％相同; （d）包含或由核苷酸分子组成的核酸分子，其与（b）的核苷酸序列相同的至少70％，优选至少80％相同，更优选至少90％相同，并且最优选95％相同; （e）关于（d）的核酸分子来退化的核酸分子; （f）（f）与（a）至（d）中任一项的核酸分子对应的核酸分子，其中T被U替换为U.
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