ANTI-DENGUE VIRUS ANTIBODIES, POLYPEPTIDES CONTAINING VARIANT FC REGIONS, AND METHODS OF USE

摘要

The present invention relates to anti-DENV antibodies and methods of making and using the same. The present invention also relates to nucleic acids encoding anti-DENV antibodies and host cells comprising said nucleic acids. Said anti-DENV antibody has use comprising treating a DENV infection. The present invention also relates to polypeptides containing variant Fc regions and methods for their preparation. The present invention also relates to nucleic acids encoding polypeptides and host cells comprising said nucleic acids. The polypeptide has uses, including treating viral infections. The present invention also relates to a polypeptide comprising an Fc variant comprising one or more amino acid alterations in a parent Fc region, wherein the variant Fc region has substantially reduced FcYR-binding activity as compared to the parent Fc region and substantially It has no reduced Clq-binding activity.