BIONIC NANOPARTICLE COATED WITH MESENCHYMAL STEM CELL MEMBRANE HAVING SURFACE OVEREXPRESSING PD-L1 MOLECULE, AND PREPARATION THEREFOR AND APPLICATION THEREOF

摘要

The present invention relates to a bionic nanoparticle coated with a mesenchymal stem cell membrane having a surface overexpressing a PD-L1 molecule, and preparation therefor and an application thereof. In the present invention, the bionic nanoparticle coated with the mesenchymal stem cell membrane having the surface overexpressing the PD-L1 molecule comprises a nanocore and a mesenchymal stem cell membrane wrapping the nanocore; the nanocore comprises a polymer having biocompatibility; and the PD-L1 molecule is overexpressed by the membrane surface of the mesenchymal stem cell membrane. Also disclosed in the present invention is an application of the bionic nanoparticle coated with the mesenchymal stem cell membrane having the surface overexpressing the PD-L1 molecule in preparation of an inflammation treatment preparation. The bionic nanoparticle of the present invention has a remarkable immunosuppressive effect, is good in biocompatibility, and simple and mature in preparation process, and may be used for preparing the inflammation treatment preparation; the preparation may be effectively concentrated in an inflammatory site, and exhibits an excellent treatment effect in inflammation treatment by suppressing excessively activated immune response and cytokine storm of the inflammatory site.