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INTRACELLULAR DELIVERY OF BIOMOLECULES FOR TOLERANCE INDUCTION
INTRACELLULAR DELIVERY OF BIOMOLECULES FOR TOLERANCE INDUCTION
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机译:用于耐受性诱导的生物分子的细胞内递送
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摘要
The present invention provides methods for inducing tolerance or suppressing an immune response to an antigen by passing a cell suspension containing an immune cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell, thereby generating a tolerogenic and/or immunosuppressive immune cell. In some embodiments, the tolerogenic and/or immunosuppressive immune cell is delivered to an individual and presentation of the antigen induces tolerance and/or suppresses an immune response to the antigen.
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