MOSAIC RECOMBINANT POLYPEPTIDE CONTAINING FRAGMENTS OF HEPATITIS E VIRUS PROTEINS OF GENOTYPES 1 AND 3 IN ONE POLYPEPTIDE CHAIN, INTENDED FOR USE IN TEST SYSTEMS USED IN THE SERODIAGNOSIS OF HEPATITIS E

摘要

FIELD: biotechnology, immunology.;SUBSTANCE: a mosaic recombinant polypeptide containing fragments of the hepatitis E virus proteins ORF2 and ORF3 of genotypes 1 and 3 in one polypeptide chain is described. The product is designed for use in test systems used in the serodiagnosis of hepatitis E.;EFFECT: genetic engineering design containing fragments of the orf2 and orf3 genes of HEV 1 and 3 genotypes in one reading frame; the strain is a producer of a mosaic recombinant polypeptide with fragments of the ORF2 and ORF3 proteins of the HEV 1 and 3 genotypes as part of one polypeptide chain; a purified mosaic recombinant polypeptide with fragments of the ORF2 and ORF3 proteins of the HEV 1 and 3 genotypes as part of one polypeptide chain. ;1 cl, 30 dwg, 9 tbl