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Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria

机译：链球菌菌丝裂解素用于革兰氏阳性细菌的检测和治疗

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摘要

The present invention provides methods, compositions and articles of manufacture useful for the prophylactic and therapeutic amelioration and treatment of gram-positive bacteria, including Streptococcus and Staphylococcus, and related conditions. The invention provides compositions and methods incorporating and utilizing Streptococcus suis derived bacteriophage lysins, particularly PlySs2 and/or PlySs1 lytic enzymes and variants thereof, including truncations thereof. Methods for treatment of humans are provided.

机译：本发明提供了用于预防和治疗改进和治疗革兰氏阳性细菌的方法，组合物和制品，包括链球菌和葡萄球菌和相关条件。本发明提供了包含和利用链球菌衍生的噬菌体溶胶，特别是填充剂2和/或吡啶胺酶及其变体的组合物和方法，包括其截风。提供了人类治疗方法。

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公开/公告号US11111484B2

专利类型
公开/公告日2021-09-07

原文格式PDF
申请/专利权人 THE ROCKEFELLER UNIVERSITY;
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申请/专利号US201916707733
发明设计人 VINCENT A. FISCHETTI;JONATHAN SCHMITZ;DANIEL GILMER;CHAD EULER;
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申请日2019-12-09
分类号C12N9/36;A61K38/16;A61K38/50;A61K38/47;A61K45/06;
国家 US
入库时间 2022-08-24 20:52:43

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