TREATMENT OF CARDIOMYOPATHY THROUGH MODULATION OF HYPOXIA-INDUCED eRNA ACTIVITY

摘要

The invention relates to an inhibitor, in particular an antisense oligonucleotide, directed against the enhancer RNA SINT1 for use in a method for the prevention or treatment of heart disease, particularly for cardiomyopathy. The antisense oligonucleotide is a gapmer or RNA interference (RNAi) agent. The antisense oligonucleotide is particularly suitable for the treatment of cardiomyopathy resulting from cardiac overload.