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FLUORESCENT PROBE FOR HIGH-SENSITIVITY PANCREATIC FLUID DETECTION, AND METHOD FOR DETECTING PANCREATIC FLUID

机译:用于高灵敏度胰液流体检测的荧光探针,以及检测胰液的方法

摘要

[Problem] To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe. [Solution] A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below. (In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R 1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R 8 and R 9 each independently represent a hydrogen atom or an alkyl group; and X represents a C 1 -C 3 alkylene group.)
机译:[问题]提供一种能够快速检测和成像的荧光探针,该荧光探针在手术期间或之后的胰液泄漏的存在,进一步提供了使用荧光探针的检测方法和检测试剂盒。 [溶液]一种用于检测含有下面式(I)所示的化合物或其盐的胰液的荧光探针。 (在式中,A代表氨基酸残基或N-取代的氨基酸残基,用相邻NH形成酰胺键; R 1表示键合的氢原子或1至4个相同或不同的取代基 用苯环; R 2,R 3,R 4,R 5,R 6和R 7各自独立地代表氢原子,羟基,烷基或卤素原子; R 8和R 9各自独立地 代表氢原子或烷基; x表示C 1 -C 3亚烷基。)

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