MOLECULARLY MODIFIED STRUCTURES OF GLP-1R ACTIVATORS AND USE OF DIMERS THEREOF IN TREATING METABOLIC DISEASES

摘要

Provided are molecularly modified structures of GLP-1R Exendin-4, GIP-Exendin-4 chimeric polypeptide, and GLP-1, said modified structures forming dimers by means of connection of disulfide bonds formed by cysteine. The modified structures can treat metabolic syndromes, including treating diabetes and obesity.