METHOD FOR PREPARING LIPOSOME SYNTHESIS CONTAINING ULTRASOUND RESPONSIVE MICROBUBBLE FOR DRUG DELIVERY AND LIPOSOME USING THE SAME

摘要

In the method for producing a liposome containing ultrasonically responsive microbubbles for drug delivery, (a) after generating ultrasonically responsive microbubbles containing an inert gas inside and having a first shell formed on the outer surface, the ultrasonic wave through the extruder uniformly forming a size distribution of reactive microbubbles; and (b) forming liposomes containing the ultrasonically responsive microbubbles and the drug having a uniform size distribution therein and having a second shell formed on the outer surface, followed by uniformly forming the size distribution of the liposomes through an extruder; It provides a method comprising a, and liposomes using the same.