USE OF PAX6 GENE OR EXPRESSION PRODUCT THEREOF IN PREPARATION OF DRUG FOR INHIBITING FIBROSIS

摘要

Provided is the use of a PAX6 gene or an expression product thereof in the preparation of a drug for inhibiting fibrosis. Experiments confirm that PAX6 can inhibit fibrosis promotion factor TGFβ and promote fibrosis inhibitory factors IL1R2 and CXCL10, so that the effects of protecting the heart and inhibiting fibrosis can be achieved, and therefore, in terms of the heart, PAX6 is a potential brand-new important target for treating heart fibrosis so as to prevent heart failure.