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GENETICALLY MODIFIED SALMON WHICH PRODUCE STERILE OFFSPRING
GENETICALLY MODIFIED SALMON WHICH PRODUCE STERILE OFFSPRING
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机译:产生无菌后代的遗传修饰的三文鱼
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摘要
The present invention relates, inter alia, to a process for making modified fish zygotes or early- stage fish embryos (particularly salmon zygotes and salmon embryos), wherein the process comprises (a) modifying the genome of the fish zygote or an early-stage fish embryo to eliminate functional expression of a germ cell survival factor gene (e.g. dead-end, dnd) and (b) introducing functional protein or RNA encoded by the germ cell survival factor gene into the zygote or early-stage embryo. The invention also provides fish zygotes, fish embryos, juvenile fish, mature fish and sterile fish which are produced by the processes of the invention.
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