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FUSION PROTEIN COMPRISING ANTI-TUMOR-ASSOCIATED ANTIGEN ANTIBODY, ANTI-PD-L1 ANTIBODY AND 4-1BBL AND USES THEREOF
FUSION PROTEIN COMPRISING ANTI-TUMOR-ASSOCIATED ANTIGEN ANTIBODY, ANTI-PD-L1 ANTIBODY AND 4-1BBL AND USES THEREOF
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机译:包含抗肿瘤相关抗原抗体,抗PD-L1抗体和4-1bbl及其用途的融合蛋白
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摘要
The present invention relates to a fusion protein comprising an anti-TAA antibody, an anti-PD-L1 antibody and 4-1BBL and uses thereof. More specifically, the present invention relates to a fusion protein comprising an anti-CEA antibody, an anti-PD-L1 antibody and 4-1BBL and uses thereof. The fusion protein of the present invention has excellent binding ability between CEA, a tumor-associated antigen, and PD-L1, an immune checkpoint protein, and can specifically bind to tumor cells expressing CEA and/or PD-L1. In addition, the fusion protein of the present invention can activate T cells without showing the toxicity seen in the existing 4-1BBL therapeutic agent. Therefore, the fusion protein of the present invention can be usefully used to treat cancer diseases.
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