FUSION PROTEIN COMPRISING ANTI-TUMOR-ASSOCIATED ANTIGEN ANTIBODY, ANTI-PD-L1 ANTIBODY AND IL-15 AND USES THEREOF

摘要

The present invention relates to a fusion protein comprising an anti-TAA antibody, an anti-PD-L1 antibody and IL-15 and uses thereof. More specifically, the present invention relates to a fusion protein comprising an anti-CEA antibody, an anti-PD-L1 antibody and IL-15 and uses thereof. The fusion protein of the present invention has excellent binding ability between CEA, a tumor-associated antigen, and PD-L1, an immune gateway, and can specifically bind to tumor cells expressing CEA and/or PD-L1. In addition, the fusion protein of the present invention can induce proliferation of T cells and NK cells, activate immune cells, and exhibit excellent anticancer effects when administered to cancer-inducing mice. Therefore, the fusion protein of the present invention can be usefully used to treat cancer diseases.