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Highly stable and specific molecular beacons encapsulated in cationic lipoplex nanoparticles and application thereof
Highly stable and specific molecular beacons encapsulated in cationic lipoplex nanoparticles and application thereof
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机译:封装在阳离子脂质体纳米颗粒及其应用中的高度稳定和特异性分子标菌
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摘要
The present invention discloses a method of detecting the presence of mutated genes, mRNAs or microRNAs in a subject. The method comprises the following steps: (1) Provide a body fluid sample containing cells, circulating tumor cells (CTCs), and/or extracellular vesicles (EVs); and use an analyzer having overhang molecular beacons to measure fluorescence signals generated by interactions between the body fluid sample and the overhang molecular beacons, so as to detect the presence of the mutated genes, mRNAs or microRNA. Furthermore, a biochip comprising a gold coating substrate and tethered lipoplex nanoparticles encapsulating the overhang molecular beacons is also provided in the invention.
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