The method for delivering the neuroprotection polypeptide to the central nervous system

摘要

The present invention provides methods for delivering a neuroprotective polypeptide to at least a portion of a subject's central nervous system (CNS). The method comprises administering to the subject's systemic blood circulation a therapeutically effective amount of a controlled-release agent of a neuroprotective polypeptide, or a group consisting of GLP-1, exendin-4, or a therapeutically effective GLP-1 analog or exendin-4 analog. administering, by a sustained release device, a neuroprotective polypeptide comprising at least one neuroprotective polypeptide selected from; The neuroprotective polypeptide binds to and activates a receptor that binds to at least one of GLP-1, exendin-4, or a combination thereof; A controlled release neuroprotective agent, or sustained release release of a neuroprotective polypeptide, improves delivery of the neuroprotective polypeptide across the blood brain barrier (BBB) to at least a portion of the CNS, compared to a rapid release formulation of the neuroprotective polypeptide . Also disclosed are methods of treating or reducing a CNS related disorder in a subject in need thereof.