Lactobacillus plantarum Novel Lactobacillus plantarum strain the strain-derived polysaccharide and its use

摘要

The present invention relates to a novel Lactobacillus plantarum IMB19 strain, a polysaccharide derived from the strain, and uses thereof. The novel Lactobacillus plantarum IMB19 strain of the present invention and the polysaccharide derived from the strain have excellent CD8 + T cell activity stimulating ability and Treg cell It exhibits inhibitory activity of CPS, and stimulates and enhances anti-tumor immune responses through various mechanisms such as increased macrophage infiltration in CPS tumors, and differentiation/reprogramming of macrophages to an inflammatory (M1) phenotype. Therefore, the strains and strain-derived polysaccharides of the present invention can be usefully used for modulation of immunity in a subject, particularly for enhancing immunity, and inducing and enhancing anti-tumor immune responses, thereby inhibiting tumor growth. The novel strains and strain-derived polysaccharides of the present invention are useful for the prevention, improvement or treatment of, for example, tumors, infectious diseases, and various immune diseases caused by or symptomatic of immune dysfunction.