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MUTANT STRAIN OF EUROPEAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND VACCINE COMPOSITION COMPRISING SAME
MUTANT STRAIN OF EUROPEAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS AND VACCINE COMPOSITION COMPRISING SAME
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机译:欧洲猪生殖和呼吸综合征病毒的突变菌株和包含该疫苗组合物的疫苗组合物
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摘要
The present invention relates to a mutant strain of European porcine reproductive and respiratory syndrome virus, in which silencing mutation is introduced into a specific site of the genome through codon pair deoptimization, and to a use thereof. The virus mutant strain provided by the present invention is attenuated and decreases in proliferative ability in pigs, compared to the wild-type strain and, as such, can be utilized as a vaccine for prevention of European porcine reproductive and respiratory syndrome.
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