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INHIBITORS OF GLUTATHIONE S-TRANSFERASES (GSTS) AND NAD(P)H:QUINONE OXIDOREDUCTASE 1 (NQO1), PHARMACEUTICAL COMPOSITIONS, AND USES IN MANAGING CANCER
INHIBITORS OF GLUTATHIONE S-TRANSFERASES (GSTS) AND NAD(P)H:QUINONE OXIDOREDUCTASE 1 (NQO1), PHARMACEUTICAL COMPOSITIONS, AND USES IN MANAGING CANCER
This disclosure relates to compounds that inhibit glutathione S-transferases (GSTs) and/or NAD(P)H:quinone oxidoreductase 1 (NQO1) for uses in treating cancer. In certain embodiments, this disclosure relates to compositions and uses of N-(thiazol-2-yl)-carboxamide derivatives such as a N-(5-nitrothiazol-2-yl)-carboxamide derivatives for treating cancer such as glioblastoma. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a N-(thiazol-2-yl)-carboxamide derivative such as a N-(5-nitrothiazol-2-yl)-carboxamide derivative which is a compound of formula (I), or derivative, prodrug or salt thereof and a pharmaceutically acceptable excipient, wherein X, R1, R2, and R3 substituents are reported herein.
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