New substituted cyano India Phosphorus Derivatives as Nik inhibitors

摘要

The present invention provides pharmaceuticals of formula (I) useful for therapy and / or prevention in mammals, and in particular NF − useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders, and autoimmune disorders. It relates to inhibitors of κB-induced kinase (NIK is also known as MAP3K14). The present invention also provides pharmaceutical compositions comprising such compounds and said compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. Concerning the use of things. [Chemical 1] [Selection figure] None