Combination therapy using notch inhibitor and PI3K / mTOR inhibitor for cancer treatment

摘要

4,4,4-Trifluoro-N-[(1S) -2-[[(7S) -5- (2-hydroxyethyl) -6-oxo-7H-pyrido [2,3-d] [3] Benzoazepine-7-yl] amino] -1-methyl-2-oxoethyl] butanamide or a pharmaceutically acceptable salt or hydrate thereof, and 8- [5- (1-hydroxy-1-methylethyl) pyridine -3-yl] -1-[(2S) -2-methoxypropyl] -3-methyl-1,3-dihydro-2H-imidazo [4,5-c] quinolin-2-one or pharmaceutically acceptable thereof Cell acute lymphoblastic leukemia, acute lymphoblastic leukemia, acute myeloid leukemia, chronic myelogenous leukemia, breast cancer, ovarian cancer, melanoma, lung cancer, pancreas, including combination therapy with salts Cancer, glioblastoma, meat , Desmoid tumor, adenoid cystic carcinoma, colorectal cancer, head and neck cancer, cervical cancer, prostate cancer, a medicament for use in the treatment of liver cancer or skin cancer. [Selected figure] None