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Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

机译：用PI3K / AKT / MTOR途径抑制剂的组合治疗克服了PIK3CA-突变体HER2阳性乳腺癌细胞抗HER2治疗的抗性

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Yumi Fujimoto; Tomoko Yamamori Morita; Akihiro Ohashi; Hiroshi Haeno; Yumi Hakozaki; Masanori Fujii; Yukie Kashima; Susumu S. Kobayashi; Toru Mukohara;
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1. OVERCOMING ENDOCRINE THERAPY RESISTANCE DUE TO PI3K/AKT PATHWAY ACTIVATION BY COMBINATIONS OF mTOR, AKT, OR MEK INHIBITORS [J] . Osborne K., Fu X., Westbrook T., The Breast : . 2013,第Suppla1期

机译：通过mTOR，AKT或MEK抑制剂的组合激活PI3K / AKT途径，克服了内分泌治疗的耐药性
2. A SYSTEMS PHARMACOLOGY MODEL TO EVALUATE TRIPLE DRUG COMBINATION THERAPY AT OVERCOMING RESISTANCE TO ANTI-HER2 THERAPY IN HER2-POSITIVE BREAST CANCER. [J] . Franco Y., Ramakrishnan V., Vaidya T., Clinical Pharmacology and Therapeutics . 2020,第S1期

机译：一种系统药理学模型，评价三重药物联合治疗在耐乳癌抗Her2疗法耐抗Her2疗法中的抗性。
3. Inhibition of CD133 Overcomes Cisplatin Resistance Through Inhibiting PI3K/AKT/mTOR Signaling Pathway and Autophagy in CD133-Positive Gastric Cancer Cells [J] . Ruiqi Lu, Gang Zhao, Yulong Yang, Technology in cancer research & treatment. . 2019,第19期

机译：CD133抑制CD133通过抑制PI3K / AKT / MTOR信号通路和CD133阳性胃癌细胞的自噬克服了顺铂抗性
4. Combination of PI3K/Akt/mTOR inhibitors and PDT in endothelial and tumor cells. [C] . Fateye, Babasola, Chen Bin Optical methods for tumor treatment and detection: mechanisms and techniques in photodynamic therapy XX . 2011

机译：内皮细胞和肿瘤细胞中PI3K / Akt / mTOR抑制剂和PDT的组合。
5. Sensitivity of MCF-7 breast cancer cells to anticancer drugs is decreased by activation of the PI3K/PDK/Akt signal transduction pathway. [D] . Navolanic, Patrick M. 2004

机译：通过激活PI3K / PDK / Akt信号转导途径，MCF-7乳腺癌细胞对抗癌药物的敏感性降低。
6. Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases [O] . Franziska Maria Ippen, Julia Katharina Grosch, Megha Subramanian, 2019

机译：用PIK3CA-突变乳腺癌脑转移靶向PI3K / AKT / MTOR途径GDC-0068
7. PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway [O] . Huayu Hu, Junyong Zhu, Yuting Zhong, 2021

机译：Pik3CA突变通过抑制细胞凋亡并激活PI3K / AKT / MTOR信号传导途径来赋予三重阴性乳腺癌化疗的抵抗力

Combination treatment with a PI3K/Akt/mTOR pathway inhibitor overcomes resistance to anti-HER2 therapy in PIK3CA-mutant HER2-positive breast cancer cells

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