PROCESS FOR PREPARING APOLIPOPROTEIN A-I Apo A-I

摘要

The present invention provides a method for obtaining apolipoprotein AI (Apo AI) from an apolipoprotein AI (Apo AI)-containing protein fraction (A), wherein the apolipoprotein AI (Apo AI)-containing protein fraction (A) is mixed with a buffer solution (B) and remove impurities from the suspension while continuing to solubilize the apolipoprotein AI (Apo AI) protein, precipitate apolipoprotein AI (Apo AI) from the suspension, and collect the apolipoprotein AI (Apo AI) precipitate It relates to a method for obtaining apolipoprotein AI (Apo AI) from apolipoprotein AI (Apo AI) containing protein fraction (A), comprising: Also provided are apolipoprotein AI (Apo AI) obtained by the method, reconstituted HDL obtained from such apolipoprotein AI (Apo AI), and a pharmaceutical composition comprising such apolipoprotein AI (Apo AI) and/or reconstituted HDL do.