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PROCESS FOR PREPARING APOLIPOPROTEIN A-I (APO A-I)
PROCESS FOR PREPARING APOLIPOPROTEIN A-I (APO A-I)
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机译:制备载脂蛋白A-I(APO A-I)的过程
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摘要
The present invention relates to processes of obtaining Apo A-1 from an Apo A-1 containing protein fraction (A), comprising suspending—the Apo A-1 containing protein fraction (A) in a buffer solution (B), removing impurities from the suspension while keeping the Apo A-1 proteins solubilized, followed by precipitating Apo A˜I from the suspension and collecting the Apo A-1 precipitate. Apo A-I obtained by such processes, reconstituted HDL obtained from such Apo A-1, and pharmaceutical compositions comprising such Apo A-I and/or reconstituted HDL also are provided.
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