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METHOD AND SYSTEM FOR DETERMINING MICROSATELLITE INSTABILITY
METHOD AND SYSTEM FOR DETERMINING MICROSATELLITE INSTABILITY
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机译:确定微卫星不稳定性的方法和系统
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摘要
Disclosed herein are methods and systems for determining microsatellite instability. In some embodiments, the disclosed methods and systems are used for determining whether a cancer patient has high microsatellite instability (MSI-H). MSI-H patients have remarkably good responses to immunotherapy, such as checkpoint inhibitors immunotherapy. Therefore, the disclosed methods and systems can be used for identifying MSI-H and thus, patients as candidates for immunotherapy. In turn, the disclosed methods and systems can be used to predict responsiveness to immunotherapy. In some embodiments, the methods further include providing an immunotherapy to the MSI-H patient. Also disclosed are vaccines and compositions.
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