Catalyst for oxidization reaction comprising complexes in which 2,6-bis(bis(2-pyridylmethyl)amino)-methyl-4-methylphenol ligand was coordinated with various transition-metal ions

摘要

The present invention relates to a metal ion and 2,6-bis[(bis(2-pyridylmethyl)amino)-methyl]-4-methylphenol (2,6-bis[(bis(2-pyridylmethyl)amino)-methyl] -4-methylphenol: H-bpmp) a catalyst for oxidation using a peroxide comprising a ligand coordinated complex; a composition for detecting pyrophosphate (PPi) and a composition for detecting pyrophosphatase (PPase) comprising the catalyst and hydrogen peroxide; And it relates to a composition for detecting a biomolecule, comprising the catalyst and an oxidase specific for the biomolecule to be analyzed. The catalyst of the present invention utilizes the peroxidase-like catalytic activity of a complex coordinated with an H-bpmp ligand and various transition metal ions, and can be used in a stable state, is inexpensive to prepare, and can be mass-produced. In addition, it is possible to colorimetrically detect pyrophosphate and pyrophosphatase, as well as biomolecules such as glucose, cholesterol, and choline, which generate hydrogen peroxide by reaction with a specific oxidase, by a simple method. It can be usefully applied to the diagnosis of diseases.