Nitric oxide releasing high density lipoprotein like nanoparticles (no HDL NPs)

摘要

Provided herein are nanostructures useful for delivering nitric oxide having a core and a lipid layer and optionally a shell such as a lipoprotein. Also provided are methods of treating diseases, including methods of treating vascular diseases, angiogenesis, ischemia reperfusion, etc. using the nanostructures. The structure may include a nanostructured core and a shell surrounding and attached to the nanostructured core, the shell being composed of a reservoir molecule comprising lipid and nitric oxide (NO). obtain.