首页>
外国专利>
Highly efficient synthesis of z-macrocycles using stereoretentive, ruthenium-based metathesis catalysts
Highly efficient synthesis of z-macrocycles using stereoretentive, ruthenium-based metathesis catalysts
展开▼
机译:高效合成Z-Macrocycles使用立体,钌的复分解催化剂
展开▼
页面导航
摘要
著录项
相似文献
摘要
A highly efficient, Z-selective ring-closing metathesis system for the formation of macrocycles using a stereoretentive, ruthenium-based catalyst supported by a dithiolate ligand is reported. This catalyst is demonstrated to be remarkably active as observed in initiation experiments showing complete catalyst initiation at −20° C. within 10 min. Using easily accessible diene starting materials bearing a Z-olefin moiety, macrocyclization reactions generated products with significantly higher Z-selectivity in appreciably shorter reaction times, in higher yield, and with much lower catalyst loadings than in previously reported systems. Macrocyclic lactones ranging in size from twelve-membered to seventeen-membered rings are synthesized in moderate to high yields (68-79% yield) with excellent Z-selectivity (95%-99% Z).
展开▼