embedded image "/> FUSED BICYCLIC COMPOUNDS USEFUL AS UBIQUITIN-SPECIFIC PEPTIDASE 30 INHIBITORS
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FUSED BICYCLIC COMPOUNDS USEFUL AS UBIQUITIN-SPECIFIC PEPTIDASE 30 INHIBITORS

机译:熔融双环化合物可用作泛素特异性肽酶30抑制剂

摘要

The present disclosure relates to compounds of formula (I′) and pharmaceutically acceptable salts thereof useful as inhibitors of Ubiquitin Specific Peptidase 30 (USP30), pharmaceutical compositions thereof, and methods of use thereof. Compounds as disclosed herein can be useful in the treatment of a disease or disorder involving mitochondrial dysfunction, including neurodegenerative diseases.; embedded image
机译:本公开涉及式(I')化合物和其药学上可接受的盐,其可用作泛素特异性肽酶30(USP30),其药物组合物及其用方法的抑制剂。如本文所公开的化合物可用于治疗涉及线粒体功能障碍的疾病或病症,包括神经变性疾病。 <化学ID =“Chem-US-00001”> “嵌入图像”文件=“US20210198263A1-20210701-C00001.GIF”他=“35.39mm”ImgContent

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