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Glucose dehydrogenase having modified electron transfer properties, and glucose measurement method
Glucose dehydrogenase having modified electron transfer properties, and glucose measurement method
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机译:具有改性电子转移性能的葡萄糖脱氢酶和葡萄糖测量方法
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摘要
A glucose dehydrogenase having modified electron transfer properties, and a glucose measurement method and measuring kit using the glucose dehydrogenase are provided. Provided are a glucose dehydrogenase having at least 1, 2 or 3 amino acid substitutions, for example, amino acid substitution with a polar amino acid or alanine, in the region corresponding to the 457th to 477th position in SEQ ID NO: 1 of a glucose dehydrogenase having homology with SEQ ID NO: 1, a glucose measurement method, a measurement reagent kit and a sensor using the glucose dehydrogenase. The electron transfer properties of the glucose dehydrogenase of the present invention is modified and can be used in measuring glucose in the presence of a mediator with reduced concentration or in the absence of a mediator, and can be used, for example, in continuous glucose measurement.
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机译:提供了具有改性电子转移性能的葡萄糖脱氢酶,以及使用葡萄糖脱氢酶的葡萄糖测量方法和测量试剂盒。是具有至少1,2或3个氨基酸取代的葡萄糖脱氢酶,例如,具有极性氨基酸或丙氨酸的氨基酸取代,在对应于葡萄糖的SEQ ID NO:1的457至477次位置的区域中脱氢酶具有与SEQ ID NO:1的同源性,葡萄糖测量方法,测量试剂盒和使用葡萄糖脱氢酶的传感器。修饰本发明的葡萄糖脱氢酶的电子转移性能,可用于测量浓度降低或在不存在介体的介体的存在下测量葡萄糖,并且可以例如在连续葡萄糖测量中使用。
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