CHIMERIC ANTIGEN RECEPTORS TARGETING B7-H3 (CD276) AND ASSOCIATED METHODS
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机译:靶向B7-H3(CD276)和相关方法的嵌合抗原受体
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摘要
In various embodiments, the present disclosure provides chimeric antigen receptors (CAR)s which bind to B7-H3. The B7-H3 CARs comprise an extracellular region comprising a binding domain that specifically binds to at least a portion of B7-H3, a transmembrane region, and an intracellular region comprising an effector domain or a portion or variant thereof and a costimulatory domain or a portion or variant thereof. Recombinant host cells expressing the CARs are also provided, as well as compositions and methods comprising the same.
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