Methods for the prevention or treatment of certain disorders by inhibiting the binding of IL-4 and / or IL-13 to their respective receptors

摘要

To provide a composition comprising a protein that inhibits IL-4 and/or IL-13 from binding to their respective receptors in order to treat, ameliorate or prevent allergic asthma, rhinitis, conjunctivitis, lung fibrosis, cystic fibrosis, chronic obstructive pulmonary disease, pulmonary alveolar proteinosis or adult respiratory distress syndrome.SOLUTION: According to the present invention, there is provided a composition comprising lipocalin mutein or a fragment or variant thereof or a fusion protein or conjugate thereof, and administered locally to the lungs, preferably by aerosol inhalation.EFFECT: The lipocalin mutein is capable of inhibiting in vivo human IL-13 induced transcript Ccl11 (eotaxin) and its potency is more effective than the IL-4 mutant.SELECTED DRAWING: None