Methods for the prevention or treatment of certain disorders by inhibiting the binding of IL-4 and / or IL-13 to their respective receptors

摘要

PROBLEM TO BE SOLVED: To treat, improve or prevent allergic asthma, rhinitis, conjunctivitis, pulmonary fibrosis, cystic fibrosis, chronic obstructive pulmonary disease, alveolar proteinosis, or adult respiratory distress syndrome. And / or a composition containing a protein that inhibits IL-13 from binding to its respective receptor. It is preferably administered topically to the lung containing a lipocalin mutane or a fragment or variant thereof or a fusion protein or conjugate thereof. Composition. A composition that is administered locally to the lungs, preferably by aerosol inhalation. [Effect] Lipocarin mutane blocks the human IL-13-inducible transcript Ccl11 (eotaxin) in vivo, and its efficacy is more effective than the IL-4 mutant. [Selection diagram] None