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Multidentate bifunctional chelating agents for radionuclide complexation in diagnostics and therapy
Multidentate bifunctional chelating agents for radionuclide complexation in diagnostics and therapy
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机译:用于诊断与治疗中放射性核素络合的多齿双官能螯合剂
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摘要
The invention relates to octadentate ligands of a general formula R1-D-X-D-X-D-X-D-E-R2, wherein D is C(O)N(OH) or N(OH)C(O), pyrimidinone or pyridinone, each X independently of any other X is a saturated or partially unsaturated, substituted or unsubstituted linker comprising 8-11 atoms selected from any of N, C, O; R1 is alkyl, cycloalkyl, arene, or heteroarene, E is a saturated or partially unsaturated, substituted or unsubstituted chain comprising 1-50 atoms and R2 is a moiety capable of selectively binding to a biomolecule, or a nanoparticle. The invention further relates to complexes of the ligand, particularly radionuclides and their use in radioimmunotherapy and imaging.
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机译:本发明涉及通式R 1℃的八月状配体,其中DXDXDXDER 2℃,其中D是C(O)N(OH)或N(OH)C(O) ,嘧啶酮或吡啶酮,每个x独立于任何其他x是包含从任何N,C,O中的8-11个原子的饱和或部分不饱和或未取代的连接物; R 1是烷基,环烷基,芳烃或杂种芳烃,E是包含1-50原子的饱和或部分不饱和的,取代或未取代的链,R 2 sup>是能够的部分选择性地结合生物分子或纳米颗粒。本发明还涉及配体的复合物,特别是放射性核素及其在放射免疫疗法和成像中的应用。
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