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MASS SPECTROMETRY IMAGING WITH SUBSTANCE IDENTIFICATION USING ION MOBILITY
MASS SPECTROMETRY IMAGING WITH SUBSTANCE IDENTIFICATION USING ION MOBILITY
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机译:使用离子迁移率与物质鉴定的质谱成像
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摘要
A method for the identification and localization of small molecule species in a histologic thin tissue section comprises the steps of: a) acquiring a mass/mobility image of the tissue section and generating a mass/mobility map of the small molecule species of interest for each pixel of the image; b) providing a second sample of the same tissue and extracting the small molecules of interest, separating them, and acquiring mass and ion mobility spectra from the separated small molecules; c) identifying the small molecules of interest using corresponding reference databases; and d) assigning identified small molecules to entries in the mass/mobility maps of the first tissue section by comparison of ion masses and mobilities of the identified species to those of the second thin tissue section.
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