CORE-SHELL STRUCTURE FOR BUILDING NORMAL AND TUMOR ORGANOID MICROENVIRONMENTS AND METHOD OF PREPARING SAME

摘要

The present invention provides a core-shell structure including a shell part and a core part, wherein the shell part includes n shells sequentially positioned from the outside to the inside, and the core part includes a core positioned inside the shell part, and n is Any one of natural numbers from 1 to 30, and when n is 1, the core is located adjacent to the inside of the first shell, and when n is any one of natural numbers from 2 to 30, it is adjacent to the inside of the n-1th shell Thus, the n-th shell is located, the n-th shell is an empty space, or is a hydrogel comprising at least one of an n-th extracellular matrix and an n-th cell, and the core is an empty space, or an extracellular matrix for a core And it is a hydrogel comprising at least one of the cells for the core, the core and the two types of n shells in contact with each other are not empty spaces at the same time, and the density of the two types of the core and the n shells in contact with each other is the same or different It relates to a core-shell structure. Thereby, it is possible to simulate a steel tube structure such as a stomach, intestine, bladder, and lung.