CORE-SHELL STRUCTURE FOR BUILDING NORMAL AND TUMOR ORGANOID MICROENVIRONMENTS AND METHOD OF PREPARING SAME

摘要

In the present invention, in a core-shell structure including a shell portion and a core portion, the shell portion includes n shells sequentially located from the outside to the inside, and the core portion includes a core located inside the shell portion, and n is If any one of 1 to 30 natural numbers, n is 1, the core is located adjacent to the inside of the first shell, and n is any one of 2 to 30 natural numbers to be adjacent to the interior of the n-1th shell. Where the n-th shell is located, the n-th shell is an empty space, or a hydrogel comprising at least one of the n-th extracellular matrix and n-th cell, and the core is an empty space, or an extracellular matrix for the core And a hydrogel comprising one or more of the cells for the core, and two of the core and n shells that are in contact with each other are not empty spaces at the same time, and the density of two of the cores and n shells that are in contact with each other is the same or different. It relates to a core-shell structure. This can simulate steel pipe structures such as the stomach, intestines, bladder and lungs.