A Noble Fusion Protein-based Nanoparticles and Uses Thereof

摘要

The present invention relates to a novel mussel adhesion protein-based nanoparticles and uses thereof, and more specifically, a functional peptide fused to a mussel adhesion protein, a fusion protein for gene or drug delivery; A method of producing a fusion protein-based nanoparticle for gene or drug delivery based on the fusion protein; Gene or drug delivery fusion protein-based nanoparticles produced by the above method; And it provides a CRISPR / CAS9 gene editing system using the nanoparticles. The nanoparticles for gene or drug delivery based on the fusion protein according to the present invention have excellent biocompatibility because the functional peptide for gene delivery is fused to the mussel adhesive protein, and since it effectively penetrates into the target cell, CRISPR/CAS9 gene editing As a system as well as a biomaterial-based gene-editing carrier and a drug carrier that carries and delivers a target drug, it can be used for the treatment and research of various diseases.