- A Noble Fusion Protein-based Nanoparticles and Uses Thereof

摘要

The present invention relates to novel mussel adhesive protein-based nanoparticles and uses thereof, and more specifically, to a fusion protein for gene or drug delivery, in which a functional peptide is fused with a mussel adhesive protein; a method of preparing fusion protein-based nanoparticles for gene or drug delivery, based on the fusion protein; fusion protein-based nanoparticles for gene or drug delivery, prepared by the method; and a CRISPR/CAS9 gene editing system using the nanoparticles. Since the functional peptide for gene delivery is fused with the mussel adhesive protein, the nanoparticles for gene or drug delivery, based on the fusion protein according to the present invention, have excellent biocompatibility, and can effectively penetrate into target cells, and thus can be used not only in the CRISPR/CAS9 gene editing system, but also in the treatment and research for various diseases as a biomaterial-based carrier for gene editing and a drug carrier that carries and delivers a target drug.