Use of the activating factor of cerenzin for nerve cell amplification and central nervous system injury

摘要

Provided herein are, for example, central nervous system (CNS) cells, such as neurons, as a whole, using activators of cereblon (CRBN), such as inhibitors of CRBN substrates or downstream proteins. A method for amplification and / or regeneration of astrocytes and oligodendrocytes. Also provided herein are amplification of neural stem cells, neural progenitor cells, or neural progenitor cells using, for example, BRD7 antagonists, Ikaros antagonists, or CRBN activators, and / or CNS of these cells It is a method related to differentiation into cells. In certain embodiments, the method further comprises differentiation of specific stem cells into neural stem cells, neural progenitor cells, or neural progenitor cells using a BRD7 antagonist, an Ikaros antagonist, or a CRBN activator. Also provided herein are methods for preventing or treating CNS cell deficiency diseases, disorders, or diseases, or symptoms thereof using, for example, a BRD7 antagonist, an Ikaros antagonist, or a CRBN activator. is there. [Selection] Figure 1