Use of nerve growth factors in eye drops for the treatment of central nervous system conditions such as Alzheimer's disease or Parkinson's disease

摘要

Nerve growth factor (NGF), in the form of a preparation for administration on the ocular surface, is proposed for use in the therapy and/or prophylaxis of pathologies affecting brain tissues and encephalic structures, with particular reference to pathologies affecting the hippocampus, cerebral cortex, basal forebrain, medial septum, Broca's diagonal band, Meynert's basal nucleus, substantia nigra pars compacta, striatum and cerebellum. Applied in the form of an external ophthalmic preparation, for example, as eye-drops or ointment, the NGF is able to pass from the ocular surface to the brain tissues, and has been found to exert a therapeutic action on pathologies of the central nervous system, and particularly on Alzheimer's Disease and Parkinson's Disease.