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Biomarkers for predicting prognosis after immunotherapy of cancer

机译:用于预测癌症免疫治疗后预测预后的生物标志物

摘要

The present invention relates to a biomarker for selecting a patient for which the occurrence of accelerated tumor progression (HPD) is predicted after treatment with an immunological anticancer drug (PD-1/PD-L1). The composition of the present invention contains two selected markers (CCR7-CD45RA-, TIGIT+), and is immune to non-small cell lung cancer patients by predicting in advance the occurrence of HPD before using an immuno-anticancer agent for cancer patients, especially non-small cell lung cancer patients. Since it is possible to decide whether to use an anticancer drug, it is expected that the life expectancy can be extended by predicting a group of patients who will show a prognosis such as accelerated progression of cancer after treatment with an immune anticancer drug early and receiving customized treatment.
机译:本发明涉及一种用于选择用免疫抗癌药物(PD-1 / PD-L1)处理后预测加速肿瘤进展(HPD)的患者的生物标志物。本发明的组合物含有两个选定的标记物(CCR7-CD45RA,TIGIT +),并通过预先预测HPD之前预测癌症患者的免疫抗癌剂之前,对非小细胞肺癌患者免疫,特别是非小细胞肺癌患者。由于可以决定是否使用抗癌药物,预计可以通过预测一组患者展示预后的患者进行预期预期寿命,这些患者在用免疫抗癌药物早期和接受治疗后加速癌症进展定制治疗。

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