Anti-PD-1/anti-HER2 natural antibody structure-type heterodimeric bispecific antibody and its preparation method

摘要

The present invention relates to a heterodimeric bispecific antibody in the form of an anti-PD-1/anti-HER2 natural antibody structure and a method for producing the same. Specifically, the present invention provides a highly stable heterodimeric anti-PD-1/anti-HER2 bispecific antibody having the characteristics of natural IgG and no mismatch between heavy and light chains, and a method for producing the same. The bispecific antibody can bind to two target molecules at the same time, and will exhibit a more excellent effect in the treatment of multiple diseases.