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Cell-mediated transient delivery of immune-enhancing molecules into the tumor microenvironment
Cell-mediated transient delivery of immune-enhancing molecules into the tumor microenvironment
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机译:细胞介导的免疫增强分子进入肿瘤微环境的瞬时递送
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摘要
A recombinant natural killer (NK) cell or T-cell composition is transfected with a nucleic acid encoding i) a homing receptor; ii) an antigen binding protein (ABP) or a chimeric antigen receptor (CAR) that specifically binds a target antigen; iii) an Fc Receptor; and/or iv) a secreted immune modulator selected from a TGFβ inhibitor and/or IL-12, where the recombinant cell is gamma (γ)-irradiated conferring inhibition of cell proliferation with transient activity of the transfected molecules including the secreted immune modulators for up to 72 hours.
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